为了做出能清除Aβ的CAR，研究者把抗Aβ抗体片段分别连接到不同受体和信号区域，实验发现改造后的细胞能专门吞噬降解Aβ，不会乱吞噬其他蛋白，在原代星形胶质细胞里也能明显增强Aβ清理。用两种抗体片段优化后，Cre-Megf10效果最好，Cre-Dectin1和Adu-Dectin1效果相近，于是选用这两种构建载体做动物实验。
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The idea that small amounts of credit could lift countries out of poverty was once one of international development’s most celebrated beliefs. Pioneered by Nobel laureate Muhammad Yunus and his Grameen Bank in Bangladesh, the model quickly spread across South Asia, sub-Saharan Africa, and Southeast Asia through the 1990s and 2000s.
Jaden Fiotto-Kaufman1
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